Comparative analysis of inbreeding parameters and runs of homozygosity islands in 2 Italian autochthonous cattle breeds mainly raised in the Parmigiano-Reggiano cheese production region

Reggiana and Modenese are autochthonous cattle breeds, reared in the North of Italy, that can be mainly distinguished for their standard coat color (Reggiana is red, whereas Modenese is white with some pale gray shades). Almost all milk produced by these breeds is transformed into 2 mono-breed branded Parmigiano-Reggiano cheeses, from which farmers receive the economic incomes needed for the sustainable conservation of these animal genetic resources. After the setting up of their herd books in 1960s, these breeds experienced a strong reduction in the population size that was subsequently reverted starting in the 1990s (Reggiana) or more recently (Modenese) reaching at present a total of about 2,800 and 500 registered cows, respectively. Due to the small population size of these breeds, inbreeding is a very important cause of concern for their conservation programs. Inbreeding is traditionally estimated using pedigree data, which are summarized in an inbreeding coefficient calculated at the individual level (F_PED). However, incompleteness of pedigree information and registration errors can affect the effectiveness of conservation strategies. High-throughput SNP genotyping platforms allow investigation of inbreeding using genome information that can overcome the limits of pedigree data. Several approaches have been proposed to estimate genomic inbreeding, with the use of runs of homozygosity (ROH) considered to be the more appropriate. In this study, several pedigree and genomic inbreeding parameters, calculated using the whole herd book populations or considering genotyping information (GeneSeek GGP Bovine 150K) from 1,684 Reggiana cattle and 323 Modenese cattle, were compared. Average inbreeding values per year were used to calculate effective population size. Reggiana breed had generally lower genomic inbreeding values than Modenese breed. The low correlation between pedigree-based and genomic-based parameters (ranging from 0.187 to 0.195 and 0.319 to 0.323 in the Reggiana and Modenese breeds, respectively) reflected the common problems of local populations in which pedigree records are not complete. The high proportion of short ROH over the total number of ROH indicates no major recent inbreeding events in both breeds. ROH islands spread over the genome of the 2 breeds (15 in Reggiana and 14 in Modenese) identified several signatures of selection. Some of these included genes affecting milk production traits, stature, body conformation traits (with a main ROH island in both breeds on BTA6 containing the ABCG2, NCAPG, and LCORL genes) and coat color (on BTA13 in Modenese containing the ASIP gene). In conclusion, this work provides an extensive comparative analysis of pedigree and genomic inbreeding parameters and relevant genomic information that will be useful in the conservation strategies of these 2 iconic local cattle breeds.     

面向老龄化社会的产品服务系统设计赋能

目的 针对面向老龄化社会的产品及产品服务系统设计,将赋能的设计理念和价值引入其中,探索设计结果提升老年人能动性和参与性的赋能品质,为设计师开展设计赋能实践提供参考.方法 以设计教学中的学生设计方案作为研究材料,邀请设计研究者参与工作坊,对设计结果的赋能属性进行分析,并通过聚类获得类别化的设计属性,产生了能描述赋能品质的属性词汇表.结果 总结了包含5组形容词组的设计赋能品质集,这一集合包含"顺应性"和"激励性"两个面向.结论 研究结果为设计师进行老龄化设计提供了知识参考,有助于提升设计师的赋能意识.揭示了设计赋能充满矛盾性的品质,提出面向老龄化的设计赋能需要在"顺应"和"激励"之间找到平衡.     

A case-deletion diagnostic for penalized calibration estimators and BLUP under linear mixed models in survey sampling

The penalized calibration technique in survey sampling combines usual calibration and soft calibration by introducing a penalty term. Certain relevant estimates in survey sampling can be considered as penalized calibration estimates obtained as particular cases from an optimization problem with a common basic structure. In this framework, a case deletion diagnostic is proposed for a class of penalized calibration estimators including both design-based and model-based estimators. The diagnostic compares finite population parameter estimates and can be calculated from quantities related to the full data set. The resulting diagnostic is a function of the residual and leverage, as other diagnostics in regression models, and of the calibration weight, a singular feature in survey sampling. Moreover, a particular case, which includes the basic unit level model for small area estimation, is considered. Both a real and an artificial example are included to illustrate the diagnostic proposed. The results obtained clearly show that the proposed diagnostic depends on the calibration and soft-calibration variables, on the penalization term, as well as on the parameter to estimate.     

Inferring kinetic dissolution of NaCl in aqueous glycol solution using a low-cost apparatus and population balance model

An experimental methodology for inferring brine dissolution rate in monoethylene glycol (MEG) solutions at different temperatures using a webcam combined with a mathematical model is presented. The measurement system is designed to track the RGB (red, green, and blue) colour variations during the dissolution process. A dynamic model augmented with the population balance equation is applied to describe the dissolution process. Moreover, the dissolution rate is consistently related to the temperature and MEG concentration through the driving force based on the Gibbs energy and chemical affinity. The applied low-cost measurement apparatus proved to be a useful resource for tracking the dissolution dynamics in a wide range of undersaturation.     

混合态二能级原子双光子过程中原子的压缩效应

本文采用时间演化算符方法和数值计算研究了相干光场与混合态二能级原子相互作用双光子过程中原子的压缩效应．结果表明：原子初始所处的混合态对原子压缩性质有较大的影响，当０．８５＜Ｓ＜１时，会周期性地呈现出短时的原子压缩效应，随着原子初始混合程度的增大，原子越来越远离压缩状态．     

地下商场空调设计问题的探讨

本文分析了地下商场的特征 ,并相应提出了地下商场通风空调设计的有关数据、方法及注意事项     

百色水利枢纽库区移民人口调查方法与体会

介绍百色水库淹没移民人口调查的内容及方法,针对实际操作过程中出现的问题,提出相应的处理办法,总结水库淹没移民人口调查思路、经验及体会.     

带有外界约束的人口扩散系统的最优出生率控制

本文考虑单边约束的依赖于年龄的人口扩散系统，讨论其最优出生率（边界）控制，得到其最优控制的存在性的必要条件。     

School-Based Child-Centered Play Therapy with Hispanic Children: Outcomes and Cultural Consideration.

Hispanic children are the fastest growing segment of the population. Numerous factors place them at-risk for school success. This study examined the effects of Child-Centered Play Therapy (CCPT) compared to a curriculum-based small group intervention with 29 Hispanic children referred for school counseling due to behavior problems. Children were assigned to treatment groups by random drawing within grade levels. Treatment was provided by Hispanic bilingual counselors. Statistical analysis revealed that, according to parent report, children receiving CCPT showed statistically significant decreases in externalizing behavior problems, compared to the curriculum-based treatment group. Effect size calculations revealed that CCPT demonstrated a large treatment effect on externalizing behavior problems and a moderate treatment effect on internalizing behavior problems. Cultural considerations and recommendations for practice and future research are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect-Size Indices for Dichotomized Outcomes in Meta-Analysis.

It is very common to find meta-analyses in which some of the studies compare 2 groups on continuous dependent variables and others compare groups on dichotomized variables. Integrating all of them in a meta-analysis requires an effect-size index in the same metric that can be applied to both types of outcomes. In this article, the performance in terms of bias and sampling variance of 7 different effect-size indices for estimating the population standardized mean difference from a 2 × 2 table is examined by Monte Carlo simulation, assuming normal and nonnormal distributions. The results show good performance for 2 indices, one based on the probit transformation and the other based on the logistic distribution. (PsycINFO Database Record (c) 2010 APA, all rights reserved)